Platycodin D

Friday, 13/06/2014  |   Uncategorized  |  no comments

Cancer: Breast cancer cell lines: MCF-7 and MDA-MB-231
Action: Anti-cancer, doxorubicin (DOX)
It has been demonstrated that platycodin D (PD) exhibits anti-cancer activities. This study aims to investigate the anti-proliferative effects of the combination of PD and doxorubicin (DOX) on human breast cancer cells (MCF-7 and MDA-MB-231 cells).
The anti-proliferative effects of different dosages of PD, DOX, and PD + DOX on MCF-7 and MDA-MB-231 cells were determined by the MTT assay. The 10 muM PD, 5 muM DOX, and 10 muM PD + 5 muM DOX induced-protein expression of apoptosis-related molecules on MCF-7 and MDA-MB-231 cells were detected by western blot.
PD enhanced anti-cancer activities of DOX were observed in both MCF-7 and MDA-MB-231 cell lines. Compared with mono treatment, the combined treatment increased the protein expression of cleaved poly (ADP-ribose) polymerase and decreased the mitochondrial membrane potential. The combined treatment with PD did not obviously increase the accumulation of DOX in MCF-7 cells (1.66 +/- 0.13 in DOX-treated group, and 1.69 +/- 0.06 in PD + DOX-treated group, P = 0.76), but it significantly increased the accumulation of DOX in MDA-MB-231 cells (1.76 +/- 0.17 in DOX-treated group, 2.09 +/- 0.02 in PD + efeito colateral do cialis DOX-treated group, P = 0.027).
The combined treatment of DOX and PD exhibited stronger anti-proliferative effects on MCF-7 and MDA-MB-231 cells than DOX and PD treatment did.
Reference
Tang Z-H, Li T, Gao H-W, et al. (2014) Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells. Chinese Medicine 2014, 9:16 doi:10.1186/1749-8546-9-16

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