The Food and Drug Administration (FDA) allows travelers from

15th Saturday, 2012  |   Uncategorized  |  no comments

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The federal government has also just said it is looking

10th Monday, 2012  |   Uncategorized  |  no comments

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Antioxidant and Anti-Inflammatory Properties of Longan (Dimocarpus longan Lour.) Pericarp

28th Tuesday, 2012  |   Inflammation  |  no comments

Huang G-J, Wang B-S, Lin W-C, et al. Evidence-Based Complementary and Alternative Medicine. Volume 2012 (2012), doi:10.1155/2012/709483 This study examined the antioxidant and anti-inflammatory activities of the water extract of longan pericarp (WLP). The results showed that WLP exhibited radical scavenging, reducing activity and liposome protection activity. In addition, WLP also inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophages. Further, administration of WLP, in the range of 100–400?mg/kg, showed a concentration-dependent inhibition on paw edema development following carrageenan (Carr) treatment in mice. The anti-inflammatory effects of WLP may be related to NO and tumor necrosis factor (TNF-?) suppression and associated with the increase in the activities of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase. Overall, the results showed that WLP might serve as a natural antioxidant and inflammatory inhibitor.

Relationship Between Soy Food Intake and Breast Cancer in China

28th Tuesday, 2012  |   Breast Cancer  |  no comments

Zhu Y-Y, Zhou L, Jiao S-C, Xu L-Z. Asian Pacific J Cancer Prev, Vol.12, 2011 Pp.2837-2840
The results of this population-based case-control study suggested that regular intake of soyfood intake, particularly very high intake of soy isoflavone and soy protein, may be associated with a reduced risk of breast cancer, particularly for premenopausal and ER+ or PR+ women. These findings are consistent with observations from in vitro and animal studies implicating the potential inhibitory effect of soy on breast carcinogenesis (Adlercreutz and Mazur, 1997).
Our study showed an inverse association between soyfood intake and breast cancer risk, which is supported by other epidemiologic studies (Lee et al., 1992; Hirose et al., 2003; Hirose et al., 2005; Kim et al., 2008) and animal experiments (Adlercreutz and Mazur, 1997). Zhang et al found a reduced risk of breast cancer in Guangdong Chinese women who had high consumption of soyfood (Greenstein et al., 1996; Key et al., 1999; Zhang et al., 2010), and other cohort studies showed a weak negative association, but not all reported the similar results (Hirayama, 1990).
As endogenous estrogen has been recognized as a cause of breast cancer, the decline of hormones after menopausal may modify the effect of soy in breast cancer carcinogenesis. The in vivo studies suggest that the isoflavones have antiestrogenic effects in high-estrogen environments and estrogenic effects in low-estrogen environments (Messina et al., 2006).
Aims: Soy food intake may be associated with reduced risk of breast cancer, by far the most frequent cancer among women, but the results are inconsistent. We aimed to investigate the relationship further in Chinese population and to assess the importance of hormone receptor status. Methods: A case-control study was conducted with totals of 183 cases and 192 controls recruited from January 2008 to January 2011 among patients admitted to the General Hospital of PLA and the Second Affiliated Hospital of Guangzhou Medical University, China. Trained interviewers conducted face-to-face interviews using a structured questionnaire to collect information on dietary habits and potential confounding factors.
Results: The highest relative to lowest soy isoflavone intake was associated with a 58% decrease risk of breast cancer (OR=0.42, 95% CI=0.22-0.80). Higher consumption of soy protein also decreased breast cancer risk, and the highest consumption reduced 54% cancer risk compared with the lowest (OR=0.46, 95%CI=0.24-0.88). The inverse association between highest intake of soy isoflavone and soy protein with the risk of breast cancer was statistically in postmenpausal women (OR=0.57, 95%CI=0.29-0.83; OR=0.50, 95%CI=0.38-0.95). In the ER/PR status stratified analysis, a significantly reduced risk was observed for ER+/PR+ breast cancer among highest intake of soy isoflavone and soy protein, with ORs of 0.47 and 0.63, respectively.
Conclusion: Our study suggested that a high intake of soy food is inversely associated with breast cancer risk, the effect depending to some extent on the hormone receptor status.