Trump for impeachment the moment he takes the oath of office

18th Sunday, 2012  |   Uncategorized  |  no comments

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Cancer as a Metabolic Disease

13th Tuesday, 2012  |   Cancer Process  |  no comments

Cancer as a Metabolic Disease by Thomas Seyfried PhD is essential background information for anyone wishing to consult with cancer patients. This is not because it provides all the answers but it puts all of us on the right track. Once on this track, we will all make faster progress, as we will be working where the problem really is such as respiratory insufficiency, anaerobic metabolism, low membrane potential, or low ATP levels. Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic

glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention. Cancer as a Metabolic Disease

She was fired from Vogue and overlooked for the top editorial

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On average, retailers are charged 65 cents more per pound of Fair Trade coffee. That might not sound like a lot, until you remember how retail markup works. Take a look at the $1.40 that the growers sell their beans for, and compare that to the $9 or $10 you pay for a pound of decent, non Billy Bob Thornton poop coffee.

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Politico pointed out that would have been before she became a

10th Saturday, 2012  |   Uncategorized  |  no comments

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The role of dietary polyphenols in tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis for cancer chemoprevention.

6th Tuesday, 2012  |   Herb or Compound  |  no comments

Szliszka E, Krol W. Eur J Cancer Prev. 2011 Jan;20(1):63-9.
Polyphenols, occurring in vegetables, fruits, herbs, spices, propolis, tea, beer, and wine play an important role in cancer chemoprevention. Dietary polyphenols exert their chemopreventive effect by multiple molecular mechanisms of action on apoptosis signaling pathways in cancer cells. In this review, we describe dietary polyphenols targeting the tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptotic pathway. TRAIL is a natural potent anticancer agent that preferentially induces apoptosis in cancer cells and is not toxic to normal cells. Soluble or expressed on immune cells, molecules of TRAIL take part in immune surveillance and defense mechanisms against tumor cells. However, some cancer cells are resistant to TRAIL-mediated cytotoxicity. The decreased expression of death receptors (TRAIL-R1, TRAIL-R2) and proapoptotic proteins or increased expression of antiapoptotic proteins in cancer cells is involved in TRAIL resistance.
There is a growing body of experimental evidence showing that polyphenols sensitize TRAIL-resistant cancer cells and markedly augment TRAIL-induced programmed death in cancer cells. These in-vitro and in-vivo studies indicate the significance of dietary polyphenols in cancer chemoprevention strategies through enhancing the apoptosis-inducing potential of TRAIL.