Expression of VEGF and its Receptors and Angiogenesis in Bone and Soft Tissue Tumours

Saturday, 06/10/2012  |   Bone Cancer  |  no comments

Hara H et al. Anticancer Research. November-December 2006 vol.26 no. 6B Pp.4307-11
Tumour angiogenesis and vascularization are essential requirements for the growth and metastasis of tumours. There is evidence that overexpression of the vascular endothelial growth factor (VEGF) is correlated with an adverse prognosis in some tumours. The expression of VEGF, its receptors and microvessel density (MVD) of bone and soft tissue tumours was evaluated. Materials and Methods: Tissue specimens of 60 patients including 30 malignant and 30 benign tumours confirmed by biopsy were examined. Expression of VEGF and its receptors (flt-1 and KDR/flk-1) was observed by immunohistochemistry. Tumour angiogenesis was assessed morphologically by measuring intratumoral MVD. Results: Semi-quantitative evaluation of immunoreactivity showed that VEGF was significantly higher in malignant tumours than in benign tumours. A correlation was found between the immunoreactivity of VEGF and KDR. Moreover, correlations were found either between MVD and VEGF or between MVD and KDR/flk-1. Conclusion: Signal transduction, in particular by VEGF and KDR, potentially contributes to the angiogenesis of bone and soft tissue tumour. Expression of VEGF receptors was reported in a variety of nonendothelial cells, including cancer cells.

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