Immunobiology and conflicting roles of the human NKG2D lymphocyte receptor and its ligands in cancer

El-Gazzar A, GrohV, Spies T.  Journal of Immunology, 2013;191(4):1509-1515.  Cancers adopt diverse strategies to safeguard their survival, which often involve blinding or incapacitating the immune response, thereby gaining battleground advantage against the host. In immune responses against cancer, an important stimulatory lymphocyte receptor is NKG2D because the tumor-associated expression of its ligands promotes destruction of […]

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