Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumour promotion response.

Ferric nitrilotriacetate (Fe-NTA) is a potent nephrotoxicant and a renal carcinogen that induces its effect by causing oxidative stress. The present study was undertaken to explore protective effect of silymarin, a flavonolignan from milk thistle (Silybum marianum), against Fe-NTA mediated renal oxidative stress, inflammation and tumour promotion response along with elucidation of the implicated mechanism(s).

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