Parthenolide was found to inhibit activation of transcription factor nuclear factor

Investigations of the anti-inflammatory properties of parthenolide, and feverfew have focused on suppression of primary inflammatory endpoints such as platelet aggregation [1] and carrageenan-induced mouse [2] and rat [3] paw edema. Additional studies have evaluated parthenolide’s inhibitory effect on inflammatory mediators including activity and expression of cyclooxygenase (COX) [4,5], generation of prostaglandins [6,7], and leukotrienes […]

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