Melanoma
Studies have shown that berberine is able to trigger apoptosis in different malignant cell lines, and can also lead to cell cycle arrest at sub-apoptotic doses. In these melanoma cell lines, berberine at low doses (12.5–50 ?M) is concentrated in mitochondria and promotes G1 arrest. In contrast, higher doses (over 50 ?M) result in cytoplasmic […]
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