Folic Acid Supplementation Adversely Affects Chemosensitivity of Colon Cancer Cells to 5-fluorouracil

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Folic acid (FA) fortification and widespread supplemental use have significantly increased folate status in North America. Furthermore, >50% of colorectal cancer patients use FA supplement. The increased folate status may interfere with cancer chemotherapy.
Cell proliferation, degree of necrosis, and expression of the selected genes did

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not significantly differ by the supplemental levels of FA. Ishiguro et al., (2016) provided data suggesting that FA supplementation may be detrimental to 5-FU chemotherapy of colon cancer and pose public health concern.
Source

Nutrition and Cancer. Volume 68, Issue 5, 2016 DOI: 10.1080/01635581.2016.1170168

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