Resveratrol in human cancer chemoprevention – Choosing the ‘right’ dose

5th Thursday, 2012  |   Herb or Compound  |  no comments

There is now robust preclinical evidence to suggest that resveratrol possesses cancer chemopreventive properties. A series of clinical pilot studies has provided insights into its pharmacokinetics, and data on its human antineoplastic pharmacodynamics start to emerge. It is likely that resveratrol will be developed further in the clinic as a putative cancer chemopreventive agent. The question that remains unresolved is: What is the most suitable dose of resveratrol for effective cancer preventive intervention? Mechanistic studies in cells in vitro have almost invariably used concentrations of resveratrol in the 10–5 to 10–4?M range, which is much higher than those which can be achieved in the human biophase after consumption of doses up to 1?g. Many of the preclinical efficacy studies in rodent models of carcinogenesis have employed doses which are dramatically above those which can be ingested with the diet. New experimental paradigms need to be used to obtain information on pharmacological changes elicited by resveratrol when present at very low concentrations or when administered at dietary-relevant doses.
Source:
Scott E, Steward WP, Gerschner AJ, Brown K. Molecular Nutrition & Food Research. Volume 56, Issue 1, pages 7–13, January 2012. DOI: 10.1002/mnfr.201100400

The scene is a stark contrast to the picture of a cold and

4th Wednesday, 2012  |   Uncategorized  |  no comments

military uniforms affect their mental state

Styles vs. Dean Ambrose and John Cena in a triple threat match: Styles will leave with the title, but this has the makings of an excellent bout. Much of the pre match issues have been between Cena and Ambrose, including some solid promo work by Cena on the “Smack Talk” post show on WWE Network.

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Green tea consumption enhances survival of epithelial ovarian cancer

3rd Tuesday, 2012  |   Herb or Compound, Ovarian/ Uterine Cancer  |  no comments


Our study investigates whether tea consumption can enhance the survival of patients with epithelial ovarian cancer, a prospective cohort study was conducted in Hangzhou, China. The cohort comprised 254 patients recruited during 1999–2000 with histopathologically confirmed epithelial ovarian cancer and was followed up for a minimum of 3 years. Two hundred forty four (96.1%) of the cohort or their close relatives were traced. The variables examined included their survival time and the frequency and quantity of tea consumed post-diagnosis. The actual number of deaths was obtained and Cox proportional hazards models were used to obtain hazard ratios and associated 95% confidence intervals (CI), adjusting for age at diagnosis, locality, BMI, parity, FIGO stage, histologic grade of differentiation, cytology of ascites, residual tumour and chemotherapeutic status. The survival experience was different between tea drinkers and non-drinkers (p < 0.001). There were 81 (77.9%) of 104 tea-drinkers who survived to the time of interview, compared to only 67 women (47.9%) still alive among the 140 non-drinkers. Compared to non-drinkers, the adjusted hazard ratios were 0.55 (95% CI = 0.34–0.90) for tea-drinkers, 0.43 (95% CI = 0.20–0.92) for consuming at least 1 cup of green tea/day, 0.44 (95% CI = 0.22–0.90) for brewing 1 batch or more of green tea/day, 0.40 (95% CI = 0.18–0.90) for consuming more than 500 g of dried tea leaves/year, and 0.38 (95% CI = 0.15–0.97) for consuming at least 2 g of dried tea leaves/batch. The corresponding dose-response relationships were significant (p < 0.05). We conclude that increasing the consumption of green tea post-diagnosis may enhance epithelial ovarian cancer survival. Source:
International Journal of Cancer. Volume 112, Issue 3, Pp. 465–9, 10 November 2004DOI: 10.1002/ijc.20456

In utero and postnatal exposure to isoflavones results in a reduced responsivity of the mammary gland towards estradiol

3rd Tuesday, 2012  |   Herb or Compound  |  no comments

Isoflavones are a class of chemical compounds. Genistein and daidzein are two isoflavones found in soy beans. These and other isoflavones are actually in many different kinds of legumes (beans), grains and vegetables. The structure of the isoflavone molecule shares some critical similarities to estrogen, one of the hormones naturally produced in our own bodies (both male and female). Estrogen is, of course, produced in female ovaries and male testes, as well as in fat cells and certain brain cells. We also have special cells in our brains, reproductive organs , liver and fat cells that respond to estrogen, by virtue of the estrogen receptors in these cells. Abstract Scope: Exposure scenarios during different stages of development of an organism are discussed to trigger adverse and beneficial effects of isoflavones (ISO). The aim of this study was to investigate how in utero and postnatal ISO exposure modulates the estrogen sensitivity of the mammary gland and to identify the underlying molecular mechanisms. Methods and results: Therefore, rats were exposed to either ISO-free (IDD), ISO-rich (IRD) or genistein-rich diet (GRD), up to young adulthood. Proliferative activity (PCNA expression) in the mammary gland at different ages and the estrogen sensitivity of the mammary gland to estradiol (E2) or genistein (GEN) in adult ovariectomized animals was determined and compared with different treatments. Treatment with E2 resulted in a significant lower proliferative and estrogenic response of the mammary gland in IRD and GRD compared with IDD. This correlates to a change in the gene expression pattern and a decrease in the ratio of estrogen receptor alpha (ER?) beta (ER?). Conclusions: Our results provide evidence that in utero and postnatal exposure to a diet rich in ISO but also to GEN reduces the sensitivity of the mammary gland toward estrogens and support the hypothesis that in utero and postnatal ISO exposure reduces the risk to develop breast cancer. Source: Molzberger AF, Vollmer G, Hertrampf T, et al. Molecular Nutrition & Food Research. 2011 DOI: 10.1002/mnfr.201100371

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1st Sunday, 2012  |   Uncategorized  |  no comments

Austinite Tim Hooper said there was one night when he was in law school were so few cabs. I remember we were trying to get a ride home and we were jumped by a group of guys who punched us in order to steal out cab because it was so hard to get a ride home. Uber and Lyft can pick up rides that originate in Austin, they can still drop off customers in Austin as long as the ride originates outside of Austin city limits.

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