Curcumin-induced anti-proliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.

11th Monday, 2010  |   Herb or Compound  |  no comments

BACKGROUND: Nuclear factor-kappaB (NF-kappaB) plays a central role in cell survival and proliferation in human melanoma; therefore, the authors explored the possibility of exploiting NF-kappaB for melanoma treatment by using curcumin, an agent with known, potent, NF-kappaB-inhibitory activity and little toxicity in humans. continue reading

Human VEGF ELISA Test Kit.

7th Thursday, 2010  |   Prostate Cancer  |  no comments

Vascular endothelial growth factor (VEGF) is a cytokine that plays an important role in tumour angiogenesis. VEGF is over-expressed in many human cancers, including prostate cancer, but circulating levels of VEGF in patients with prostate cancer have not been reported. In this study, we analysed plasma concentrations of VEGF in a cohort of patients with prostate cancer and compared them with a normal population. continue reading

Anticancer effects of Chinese herbal medicine, science or myth?

7th Thursday, 2010  |   Herb or Compound  |  no comments

Currently there is considerable interest among oncologists to find anticancer drugs in Chinese herbal medicine (CHM). In the past, clinical data showed that some herbs possessed anticancer properties, but western scientists have doubted the scientific validity of CHM due to the lack of scientific evidence from their perspective. continue reading

A new dawn for the use of traditional Chinese medicine in cancer therapy

6th Wednesday, 2010  |   Herb or Compound  |  1 comment

Although traditional Chinese medicine has benefitted one fifth of the world’s population in treating a plethora of diseases, its acceptance as a real therapeutic option by the West is only now emerging. In light of a new wave of recognition being given to traditional Chinese medicine by health professionals and regulatory bodies in the West, an understanding of their molecular basis and highlighting potential future applications of a proven group of traditional Chinese medicine in the treatment of a variety of cancers is crucial – this is where their calling holds much hope and promise in both animal and human trials. continue reading

Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis

6th Wednesday, 2010  |   Herb or Compound  |  1 comment

Cisplatin chemotherapy often causes acute kidney injury in cancer patients. The causative mechanisms of cisplatin-induced acute kidney injury include renal inflammation, activation of p53 tumour suppressor protein and tubular apoptosis. Luteolin, a flavone found in medicinal herbs and plants, has been reported to exhibit anti-inflammatory, antioxidant and anticarcinogenic activities. The purpose of this study was to investigate the anti-apoptotic effect of luteolin on cisplatin-induced acute kidney injury and the molecular mechanism. continue reading