The efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer

Wednesday, 21/03/2012  |   Others  |  no comments


Emerging evidences showed that CHM could suppress the proliferation of colorectal cancer cells and activate apoptosis in different mechanisms.(1-3) However, the efficacy of the combined use of CHM and chemotherapy on colorectal cancer remains controversial. In China, it is common to use CHM combined with chemotherapy to treat colorectal cancer, but no systematic review has been published in English language which hinder it to gain worldwide recognition.
This review comprises the current available RCTs to provide evidence for the use of CHM as an adjunctive therapy for colorectal cancer. We found that the combined therapy significantly improved the survival, tumor response, and performance status of colorectal cancer patients. We also found that the combined therapy significantly enhanced the immune system and reduced the side effects of chemotherapy, including nausea and vomiting, appetite loss, and diarrhea.
Source:
Zhong LLD, Chen H-Y, Cho WCS, et al. The efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: A systematic review and meta-analysis. Complementary Therapies in Medicine. 2012 doi:10.1016/j.ctim.2012.02.004
References:
1. Lin SY, Liu JD, Chang HC, Yeh SD, Lin CH, Lee W. Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. J Cell Biochem 2002;84(3):532—44, doi:10.1002/jcb.10059. PMID: 11813258.
2. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A, et al. Thymoquinone extracted from black
seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 2004;25(4): 857—66.
3. He BC, Gao JL, Luo X, Luo J, Shen J, Wang L, et al. Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation

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