How immune cells can promote cancer progression

Monday, 17/12/2012  |   Others, Reports  |  no comments

Jemima Escamilla on Tue, Dec 11, 2012 The myeloid lineage in tumors, generally termed myeloid suppressor cells (MSC), are considered key in the aberrant growth promotion of tumor cells and suppression of the anti-tumor immune response. They are considered the major inflammatory cells of many solid tumors, including breast and prostate.

MSCs in tumors include, tumor associated macrophages (TAM), polymorphonuclear and monocytic myeloid derived suppressor cells (PMN and MO-MDSC). Similar to T-cells, MSC activity can also be modulated by signaling factors from the microenvironment and can be induced to become more anti-tumor and pro-inflammatory. MSCs share similar functions and their role in cancer promotion is said to be several fold. First, they can suppress the adaptive immune response and thus function as regulators of anti-tumor T-cell activity. Second, they can induce angiogenesis through secretion of vascular endothelial growth factors (VEGFs) and matrix remodeling enzymes. Additionally, they can also promote growth and proliferation by secreting growth factors such as epidermal growth factor (EGF), fibroblast growth factors (FGFs) among others. In non-pathological conditions, myeloid derived cells play a large role in wound repair also by promoting angiogenesis, growth and proliferation. Therefore, it is easy to deduce that during chemotherapy or any type of anti-tumor treatment a dying tumor cell may appear as a wound that needs repair or healing. The myeloid lineage in tumors, generally termed myeloid suppressor cells (MSC), are considered key in the aberrant growth promotion of tumor cells and suppression of the anti-tumor immune response. They are considered the major inflammatory cells of many solid tumors, including breast and prostate. MSCs in tumors include, tumor associated macrophages (TAM), polymorphonuclear and monocytic myeloid derived suppressor cells (PMN and MO-MDSC). Similar to T-cells, MSC activity can also be modulated by signaling factors from the microenvironment and can be induced to become more anti-tumor and pro-inflammatory.

MSCs share similar functions and their role in cancer promotion is said to be several fold. First, they can suppress the adaptive immune response and thus function as regulators of anti-tumor T-cell activity. Second, they can induce angiogenesis through secretion of vascular endothelial growth factors (VEGFs) and matrix remodeling enzymes. Additionally, they can also promote growth and proliferation by secreting growth factors such as epidermal growth factor (EGF), fibroblast growth factors (FGFs) among others. In non-pathological conditions, myeloid derived cells play a large role in wound repair also by promoting angiogenesis, growth and proliferation. Therefore, it is easy to deduce that during chemotherapy or any type of anti-tumor treatment a dying tumor cell may appear as a wound that needs repair or healing.

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