Berberine inhibits angiogenic potential of Hep G2 cell line through VEGF down-regulation in vitro.

Saturday, 06/10/2012  |   Herb or Compound  |  no comments

Jie Sh et al. Journal of Gastroenterology and Hepatology. Volume 26, Issue 1, pages 179–185, January 2011 DOI: 10.1111/j.1440-1746.2010.06389.x
Background and Aim:  Berberine, an herbal alkaloid, has been reported to have promotion potential of apoptosis and anticancer effect on a variety of human tumour cells. To obtain more specific understanding of those consequences of berberine on hepatocellular carcinoma (HCC) and the tumour microenvironment, we conducted in vitro experiments to investigate the inhibitory effect of berberine on tumour-induced angiogenesis using HCC cells and human umbilical vein endothelial cells (HUVECs)
Berberine inhibited the capacity of HCC to stimulate HUVEC’s proliferation, migration and endothelial tube formation, suggesting that berberine could influence the cross-talk between the HCC cell and vascular endothelial cells. These results demonstrate berberine’s antiangiogenesis property and its clinical potential as an inhibitor of tumor angiogenesis. Subsequently analyses reveal that berberine prevents secretion of VEGF from HCC and down-regulates VEGF mRNA expression.
Conclusion:  These findings strongly suggest that berberine is a potential antiangiogenic agent

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