Cancer as a Metabolic Disease

Tuesday, 13/11/2012  |   Cancer Process  |  no comments

Cancer as a Metabolic Disease by Thomas Seyfried PhD is essential background information for anyone wishing to consult with cancer patients. This is not because it provides all the answers but it puts all of us on the right track. Once on this track, we will all make faster progress, as we will be working where the problem really is such as respiratory insufficiency, anaerobic metabolism, low membrane potential, or low ATP levels. Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic

glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention. Cancer as a Metabolic Disease

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