STAT5 promotes metastatic behaviour of human prostate cancer cells in vitro and in vivo.

There are no effective therapies for disseminated prostate cancer. Constitutive activation of signal transducer and transcriptional activator 5 (STAT5) in prostate cancer is associated with cancer lesions of high histological grade. It has been shown that STAT5 is activated in 61% of distant metastases of clinical prostate cancer.

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