Indole-3-carbinol Inhibits Telomerase Activity and Gene Expression in Prostate Cancer Cell Lines

Indole-3-carbinol (I3C) is a phytochemical with anticarcinogenic properties. Telomerase activity is key in carcinogenesis. We investigated the effect of I3C on telomerase in human prostate cancer cell lines LNCaP and PC3. Materials and Methods: Cells were treated with I3C at 100 and 250 ?M with and without 10-50 ?M diethylstilbestrol (DES). Telomerase activity was performed […]

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