Celastrol from Tripterygium wilfordii Hook new therapeutic agent for prostate cancer
Friday, 10 June 2011. Posted in CANCER THUNDER OF GOD VINE An example of natural chemicals is Thunder of God Vine (Tripterygium wilfordii Hook), from which scientist have obtained an active constituent, a triterpene extracted from the plant that has shown important anti-cancer properties, Celastrol. Tripterygium wilfordii for cancer treatment seems to be this way [...]
read morePsoralidin, an Herbal Molecule from Psoralea corylifolia, Inhibits Phosphatidylinositol 3-Kinase–Mediated Akt Signaling in Androgen-Independent Prostate Cancer Cells
Kumar R, Srinivasan S, Koduru S, et al. Cancer Prev Res March 2009 2; 234. doi: 10.1158/1940-6207.CAPR-08-0129 The protein kinase Akt plays an important role in cell proliferation and survival in many cancers, including prostate cancer. Due to its kinase activity, it serves as a molecular conduit for inhibiting apoptosis and promoting angiogenesis in most [...]
read moreIndole-3-carbinol Inhibits Telomerase Activity and Gene Expression in Prostate Cancer Cell Lines
Indole-3-carbinol (I3C) is a phytochemical with anticarcinogenic properties. Telomerase activity is key in carcinogenesis. We investigated the effect of I3C on telomerase in human prostate cancer cell lines LNCaP and PC3. Materials and Methods: Cells were treated with I3C at 100 and 250 μM with and without 10-50 μM diethylstilbestrol (DES). Telomerase activity was performed [...]
read moreComplications After Prostate Biopsy: Data From SEER-Medicare
Loeb S et al. The Journal of Urology. Volume 186, Issue 5 , Pp 1830-4, November 2011 Purpose More than 1 million prostate biopsies are performed annually among Medicare beneficiaries. We determined the risk of serious complications requiring hospitalization. We hypothesized that with emerging multidrug resistant organisms there may be an increasing risk of infectious [...]
read moreInactivation of Nuclear Factor κB by Soy Isoflavone Genistein Contributes to Increased Apoptosis Induced by Chemotherapeutic Agents in Human Cancer Cells
Li Yw, Fakhara A, Shadan A, et al. Cancer Res August 1, 2005 65; 6934. doi: 10.1158/0008-5472.CAN-04-4604 Cancer chemotherapeutic strategies commonly require multiple agents. However, use of multiple agents contributes to added toxicity resulting in poor treatment outcome. Thus, combination chemotherapy must be optimized to increase tumor response and at the same time lower its [...]
read moreThe Tumor Microenvironment and Cell to Cell communication
CLU (Clusterin) “In and Out”: Looking for a Link Cancer cells need to interact synergistically with their surrounding microenvironment to form a neoplasm and to progress further to colonize distant organs. The microenvironment can exert profound epigenetic effects on cells through cell-derived interactions between cells, or through cell-derived factors deposited into the microenvironment. Tumor progression [...]
read moreMechanistic issues concerning cancer prevention by tea catechins
Mechanistic issues concerning cancer prevention by tea catechins The cancer preventive activities of tea (Camellia sinensis, Theaceae) have been demonstrated in animal models for cancers at different organ sites and suggested by some epidemiological studies. Many mechanisms for cancer prevention have been proposed based on studies in cell lines, which demonstrated the modulation of signal [...]
read moreRole of Phytoestrogens in Inflammation
Inflammation Inflammation is a biological response of vascular tissue and is important for immune response and wound healing (Darby & Hewitson, 2007). However, in cancer, inflammation can create a microenvironment around the tumor, resulting in the attraction of chemokines, cytokines, selectins, and tumor-associated macrophages. Instead of their normal function of phagocytosis of tumor cells, they [...]
read morePhytochemical Glyceollins, Isolated from Soy, Mediate Antihormonal Effects through Estrogen Receptor α and ß1
Phytochemical Glyceollins, Isolated from Soy, Mediate Antihormonal Effects through Estrogen Receptor α and ß1 The flavonoid family of phytochemicals, particularly those derived from soy, has received attention regarding their estrogenic activity as well as their effects on human health and disease. In addition to these flavonoids other phytochemicals, including phytostilbene, enterolactone, and lignans, possess endocrine [...]
read moreSoy Isoflavones Alter Expression of Genes Associated with Cancer Progression, Including Interleukin-8, in Androgen-Independent PC-3 Human Prostate Cancer Cells
High consumption of soy isoflavones in Asian diets has been correlated with a lower incidence of clinically important cases of prostate cancer. The chemopreventive properties of these diets may result from an interaction of several types of isoflavones, including genistein and daidzein. The present study investigated the effects of a soy isoflavone concentrate (ISF) on [...]
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