Tocotrienols fight cancer by targeting multiple cell signaling pathways.
Tocotrienols fight cancer by targeting multiple cell signaling pathways. Abstract: Cancer cells are distinguished by several distinct characteristics, such as self-sufficiency in growth signal, resistance to growth inhibition, limitless replicative potential, evasion of apoptosis, sustained angiogenesis, and tissue invasion and metastasis. Tumor cells acquire these properties due to the dysregulation of multiple genes and associated [...]
read moreInactivation of Nuclear Factor κB by Soy Isoflavone Genistein Contributes to Increased Apoptosis Induced by Chemotherapeutic Agents in Human Cancer Cells
Li Yw, Fakhara A, Shadan A, et al. Cancer Res August 1, 2005 65; 6934. doi: 10.1158/0008-5472.CAN-04-4604 Cancer chemotherapeutic strategies commonly require multiple agents. However, use of multiple agents contributes to added toxicity resulting in poor treatment outcome. Thus, combination chemotherapy must be optimized to increase tumor response and at the same time lower its [...]
read moreEffects of dietary flavonoids, luteolin and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells
Highly invasive A431-III cells, which are derived from parental A431-P cells, were originally isolated via three successive passages through a Boyden chamber using a Matrigel-coated membrane support. The greater invasion potential exhibited by A431-III cells was due to their increased ability to spread/migrate, which was associated with enhanced MMP activity. The tumor progression events evoked [...]
read moreEvidence That Serum Levels of the Soluble Receptor for Advanced Glycation End Products Are Inversely Associated with Pancreatic Cancer Risk: A Prospective Study
Cigarette smoking, obesity, type 2 diabetes, and, to a lesser extent, meat cooked at high temperatures are associated with pancreatic cancer. Cigarette smoke and foods cooked at higher temperatures are major environmental sources of advanced glycation end products (AGE). AGEs accumulate during hyperglycemia and elicit oxidative stress and inflammation through interaction with the receptor for [...]
read moreGinkgo flavonoid inhibits pancreatic cancer in vitro
Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. BACKGROUND: Kaempferol is one of the most important constituents in ginkgo flavonoids. Recent studies indicate kaempferol may have antitumor activities. The objective of this study was to determine the effect and mechanisms of kaempferol on pancreatic cancer cell proliferation and apoptosis. [...]
read moreEpicatechin gallate (ECG) and catechin gallate (CG) are superior to epigallocatechin gallate (ECGC) in growth suppression and anti-inflammatory activities in pancreatic tumour cells
Epicatechin gallate (ECG) and catechin gallate (CG) are superior to epigallocatechin gallate (ECGC) in growth suppression and anti-inflammatory activities in pancreatic tumour cells Green tea catechins are considered as possible cancer preventive agents for several cancer types but little is known regarding their effects on pancreatic cancer cells. The best studied catechin and the major [...]
read moreCurcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs
Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and curry powder in the West), has been consumed by people for centuries as a dietary component and for a variety of proinflammatory ailments. Extensive research within the last decade in cell culture and in rodents [...]
read moreCancer screening among patients with advanced cancer.
A sizeable proportion of patients with advanced cancer continue to undergo cancer screening tests that do not have a meaningful likelihood of providing benefit. Screening for diseases is accepted as valuable by most physicians and patients. However, screening in patients with terminal illnesses, for whom long-term preventive benefit is nil, would seem to be a [...]
read moreIncreasing Obesity: Increasing Cancer
The estimated number of cancer cases linked to excess body fat is now at over 103,000 per year. With a new report showing that the rates of obesity continue to rise, Americans will likely experience a corresponding increase in the national cancer rate in the years ahead, say AICR experts.
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