Cell Hypoxia: the Prime Cause of Cancer on Cell Level
Figure 1. Tumour hypoxia. When a small, localised tumour outgrows its vascular supply (distances >100 ?m) tumour hypoxia arises in regions with impaired oxygen delivery. Consequently, hypoxic cells switch on target genes involved in angiogenesis [vascular endothelial growth factor (VEGF)], glucose transport [glucose transporter 1 (GLUT-1)] and cell migration [urokinase-type plasminogen activator receptor (u-PAR) and [...]
read moreDiet and Cancer Research
Diet and cancer: facts and controversies. Evidence continues to mount that dietary components are important determinants of cancer risk and tumor behavior. Although these linkages are fascinating, numerous inconsistencies are also evident in the literature. Although multifactorial, these discrepancies likely reflect variation in the ability of food constituents to reach and/or modify critical molecular targets. [...]
read moreVitamin E Attacked Again, of Course Because it Works.
Orthomolecular Medicine News Service, October 14, 2011 by Andrew W. Saul Editor, Orthomolecular Medicine News Service (OMNS, Oct 14, 2011) The very first Orthomolecular Medicine News Service release was on the clinical benefits of vitamin E. That was seven years ago. (1) In fact, the battle over vitamin E has been going full-tilt for over [...]
read moreVitamin K intake and risk of non-Hodgkin lymphoma (NHL)
Cerhan J et al (2010) from the Mayo Clinic found that people who have higher intakes of vitamin K from their diet have a lower risk of developing non-Hodgkin lymphoma (NHL). While studying the link between diet and NHL risk, they became interested in a potential role for vitamin K. Well known for its essential [...]
read moreCancer chemoprevention by dietary polyphenols: Promising role for epigenetics
Link A, Balaguer F, Goel A. Biochemical Pharmacology. Volume 80, Issue 12, 15 December 2010, Pages 1771-1792, (Inflammation 2010 – Inflammatory Cell Signalling Mechanisms as Therapeutic Targets). doi:10.1016/j.bcp.2010.06.036 Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but play an important role in the control of gene expression. In mammals, [...]
read moreLate treatment Bio-Medical Chemotherapy; Too Costly, Little Benefit?
Delivering affordable cancer care in high-income countries The burden of cancer is growing, and the disease is becoming a major economic expenditure for all developed countries. In 2008, the worldwide cost of cancer due to premature death and disability (not including direct medical costs) was estimated to be US$895 billion. This is not simply due [...]
read moreStress, Aging and Cancer
Association between urinary excretion of cortisol and markers of oxidatively damaged DNA and RNA in humans. Chronic psychological stress is associated with accelerated ageing, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated [...]
read moreMesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids
Omega 3 is contraindicated in Chemotherapy. The development of resistance to chemotherapy is a major obstacle for lasting effective treatment of cancer. Here, we demonstrate that endogenous mesenchymal stem cells (MSCs) become activated during treatment with platinum analogs and secrete factors that protect tumor cells against a range of chemotherapeutics. Through a metabolomics approach, we [...]
read moreExercise Associated with Longer Survival After Brain Cancer Diagnosis
By Duke Medicine News and Communications Brain cancer patients who are able to exercise live significantly longer than sedentary patients, scientists at the Duke Cancer Institute report. The finding, published online Monday in the Journal of Clinical Oncology, adds to recent research that exercise improves how cancer patients feel during and after treatments, and may [...]
read moreCancer stem cells and their niche
Iwasaki H & Suda T. Cancer Science. Volume 100, Issue 7, pages 1166–1172, July 2009 DOI: 10.1111/j.1349-7006.2009.01177.x The unique characteristics of stem cells, specifically pluripotency and self-renewal, are critical for sustaining the lifelong functionality of organs. Stem cells reside in a special microenvironment called the niche. Stem cells interact with the niche via adhesion molecules [...]
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