Can We Treat Cancer for a Dollar a Day? In high-income countries, we are becoming accustomed to the public debate surrounding the licensing of expensive new anticancer agents, many of which are associated with marginal clinical benefits.
David J. Kerr, M.D., D.Sc., and Rachel Midgley, M.D. N Engl J Med 2010; 363:801-803August 26, 2010 In 2002, approximately 7.6 million people worldwide died of cancer. These deaths accounted for 13% of all deaths worldwide in that year and, perhaps surprisingly, exceeded the number of deaths from HIV–AIDS, tuberculosis, and malaria combined (which totaled [...]
read moreSilymarin protects against renal cancer and acts plausibly by virtue of its antioxidant, anti-inflammatory and antiproliferative activities.
Ferric nitrilotriacetate (Fe-NTA) is a potent nephrotoxicant and a renal carcinogen that induces its effect by causing oxidative stress. The present study was undertaken to explore protective effect of silymarin, a flavonolignan from milk thistle (Silybum marianum), against Fe-NTA mediated renal oxidative stress, inflammation and tumour promotion response along with elucidation of the implicated mechanism(s). [...]
read moreCancer Stem Cells and Chinese Herbal Medicine
The deepening of our understanding of normal biology has made it clear that stem cells have a critical role not only in the generation of complex multicellular organisms, but also in the development of tumours. Recent findings support the concept that cells with the properties of stem cells are integral to the development and perpetuation [...]
read moreIncreasing Obesity: Increasing Cancer
The estimated number of cancer cases linked to excess body fat is now at over 103,000 per year. With a new report showing that the rates of obesity continue to rise, Americans will likely experience a corresponding increase in the national cancer rate in the years ahead, say AICR experts.
read moreCell Adhesion Molecules: Role and Clinical Significance in Cancer
The metastatic dissemination of tumour cells is the leading cause of morbidity and mortality in patients with cancer, since it designates the transition from a localised, potentially curable to a generalised, usually incurable disease. Tumour metastasis is considered to be a multi-step process characterised by a high degree of complexity.
read moreMuscle strength predicts cancer mortality
Men in a longitudinal study observing exercise patterns in Texas were tested for muscle strength using maximum leg and bench press measurements. A group of 8,677 men were followed for over 20 years, and cancer deaths were recorded. Men in the lowest third of muscle strength were most likely to die of cancer, a statistically [...]
read moreShort Telomeres Are Associated with Excess Cancer Incidence and Mortality;
Short Telomeres Are Associated with Excess Cancer Incidence and Mortality; A prospective study suggests that telomere length and cancer incidence are related. Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and may thereby increase cancer risk. The progressive shortening of telomeres — [...]
read moreMuscle strength predicts cancer mortality
Men in a longitudinal study observing exercise patterns in Texas were tested for muscle strength using maximum leg and bench press measurements. A group of 8,677 men were followed for over 20 years, and cancer deaths were recorded. Men in the lowest third of muscle strength were most likely to die of cancer, a statistically [...]
read moreCell Adhesion Molecules: Role and Clinical Significance in CancerCell Adhesion Molecules: Role and Clinical Significance in Cancer
The metastatic dissemination of tumour cells is the leading cause of morbidity and mortality in patients with cancer, since it designates the transition from a localised, potentially curable to a generalised, usually incurable disease. Tumour metastasis is considered to be a multi-step process characterised by a high degree of complexity. More specifically, the metastatic cascade [...]
read moreAncient Endogenous Retrovirus Genes Might Contribute to Lymphomas; these gene sequences might hold the key to other diseases as well.
Endogenous retroviruses (ERVs) integrated into human genome after cross-species infectious events millions of years ago. Few of the ERVs retain the basic structure of the integrated proviral form of infectious retroviruses. Human endogenous retroviruses (HERVs) represent a key molecular link between the host genome and infectious viral particles.
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