Is Radiation Therapy A Necessity?
by Ralph W. Moss, PhD Sunday, 28 November 2010 A standard treatment for early-stage breast cancer is to remove the tumor via lumpectomy and then follow that with radiation therapy and the drug, tamoxifen. But a report presented at the 2010 annual meeting of the American Society of Clinical Oncology (ASCO) has called this approach [...]
read moreReported Intake of Selected Micronutrients and Risk of Colorectal Cancer
Aim: The impact of micronutrient intake and colorectal cancer (CRC) risk is poorly understood. The objective of this study was to evaluate the associations of selected micronutrients with risk of incident CRC in study participants from Newfoundland, Labrador (NL) and Ontario (ON), Canada. Materials and Methods: We conducted a population-based study among 1760 case participants [...]
read moreEffects of Silybinin on the Pharmacokinetics of Tamoxifen and Its Active Metabolite, 4-Hydroxytamoxifen in Rats
The effects of silybinin, an antioxidant, on the pharmacokinetics of tamoxifen and its metabolite, 4-hydroxytamoxifen, were investigated in rats. A single dose of tamoxifen was administered intravenously (2 mg/kg) and orally (10 mg/kg) without or with silybinin (0.5, 2.5 and 10 mg/kg) to rats. Silybinin significantly altered the pharmacokinetics of orally administered tamoxifen. Compared to [...]
read moreThe role of bone microenvironment, vitamin d and calcium.
Starting first from Paget’s “seed and soil” to the latest hypothesis about metastatic process involving the concept of a premetastatic niche, a large amount of data suggested the idea that metastatization is a multistep coordinated process with a high degree of efficiency. A specific subpopulation of cells with tumor-initiating and migratory capacity can selectively migrate [...]
read moreCancer Stem Cells
Nuclear structure in A: normal cell and B: cancer cell Tumour sample from different patients and even cells within the same tumour shows significant discrepancy in morphology, proliferative potential, ability for metastasis and invasion as a reflection of variation in genetic and epigenetic aberrations (Curr Biol No.20. 2010 doi:10.1016/j.cub.2010.07.007). The ability to form a tumour [...]
read moreStress and Cancer; Some Critical Questions
1. How does one satisfactorily define “stress”? 2. How can one scientifically measure”stress”? 3. How can one define or distinguish between acute and chronic stress, since they so clearly impact the organism so differently? 4. How can one ascertain when or where a malignancy first begins? 5. How can one determine the duration between initial [...]
read moreData from National Center for Nanoscience & Technology Provide New Insights into Nanoparticles
New research, “Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatment,” is the subject of a report. “Functionalization of nanostructures such as gold nanoparticles (AuNPs) with different biological molecules has many applications in biomedical imaging, clinical diagnosis and therapy. Researchers mostly employed AuNPs larger than 10 nm for different biological and medicinal applications [...]
read moreEvidence-based Chinese medicine for cancer therapy
V. Badireenath Konkimalla, Thomas Efferth. Journal of Ethnopharmacology. Volume 116, Issue 2, 5 March 2008, Pages 207–210 http://dx.doi.org/10.1016/j.jep.2007.12.009 Abstract In contrast to western medicine (WM), traditional Chinese medicine (TCM) does not focus on a single target but on multiple targets involved in a particular disease condition by applying diverse modalities, such as herbal medicine, acupuncture, [...]
read moreCancer: A de-repression of a default survival program common to all cells?
When reading the below article, I was struck by the traits of the cancer cell (Table 1) and how it is so much like modern life. Cancer cells act not unlike many citizens in a dysfunctional country. They are self absorbed, selfish and unwilling to cooperate even in the face of the society, or the [...]
read moreAromatase inhibitors (AIs) and Isoflavones
The isoflavone genistein (GEN) and the mammalian lignans enterolactone (EL) and enterodiol (ED) would inhibit the activity of aromatase and 17β-HSD type 1 in MCF-7 cancer cells, thereby decreasing the amount of estradiol (E2) produced and consequently cell proliferation. Results showed that 10 μM EL, ED and GEN significantly decreased the amount of estrone (E1) [...]
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