Barriers to Cancer Development
Cancer is a disease of the old. Before cancer becomes symptomatic, it is believed that there usually exist a long latency period, often about 20-30 years. In other words, the initial trigger that induces cancer development occurs many years before the actual development of cancer. It is well known that the treatment of cancer is [...]
read moreExperimental Anti-Cancer Drug Kills Brain Tumor Stem Cells
The process by which Sonic Hedgehog (shh) is secreted from cells in the notochord from transcription to secretion. The original protein product undergoes cholesterol-mediated cleavage. ScienceDaily (Aug. 30, 2007) — A drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells [...]
read moreIn Vitro and In Vivo Effects of Phenolic Antioxidants against Cisplatin-Induced Nephrotoxicity
Rao M, Kumar MM, Rao MA. J Biochem (1999) 125 (2): 383-390. We have investigated the effect of phenolic antioxidants on cisplatin-induced cytotoxicity in vero (African Green Monkey Kidney) cells and in rat renal cortical slices in vitro, and on cisplatin-induced nephrotoxicity in rats in vivo. Incubation of cisplatin with vero cells resulted in time- [...]
read moreImmune Enhancement, Avoidance of Interactions Are Keys to Chemotherapy Support
By Janet Gulland. Holistic Primary Care. Vol. 12, No. 1. Spring, 2011 It is no secret that many people with cancer take nutraceuticals and botanical medicines in conjunction with conventional chemotherapy, in the hope of enhancing the therapeutic effect, minimizing side effects, and improving their odds of a long, relatively healthy life. The impulses are [...]
read moreCore signaling pathways in human pancreatic cancers revealed by global genomic analyses.
There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we performed a comprehensive genetic analysis of 24 pancreatic cancers. We first determined the sequences of 23,219 transcripts, representing 20,661 protein-coding genes, in these samples. Then, we searched [...]
read moreGreco-Arab and Islamic Herbal-Derived Anticancer Modalities: From Tradition to Molecular Mechanisms
Hilal Zaid, Michael Silbermann, Eran Ben-Arye, and Bashar Saad Evid Based Complement Alternat Med. 2012; 2012: 349040. Published online 2011 November 22. doi: 10.1155/2012/349040 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract [...]
read moreLab Mistakes Hobble Cancer Studies But Scientists Slow to Take Remedies
AMY DOCKSER MARCUS. Wall Street Journal. 20 April 2012 Last year, cancer researcher Robert Mandic got news no scientist wants to hear. After publishing a paper on a rare head-and-neck cancer, he learned the cells he had been studying were instead cervical cancer. He notified the journal Oral Oncology, which retracted the article. “To base [...]
read moreVitamin E analogues as a novel group of mitocans: Anti-cancer agents that act by targeting mitochondria
Mitochondria have recently emerged as new and promising targets for cancer prevention and therapy. One of the reasons for this is that mitochondria are instrumental to many types of cell death and often lie downstream from the initial actions of anti-cancer drugs. Unlike the tumour suppressor gene encoding p53 that is notoriously prone to inactivating [...]
read moreCancer and the contribution of Complementary and Alternative Medicine (CAM)
A Round Table Meeting of the European Parliament Interest Groups MEPs Against Cancer and MEPs for CAM on the above topic took place on Tuesday 27th March 2012 in the European Parliament. A European survey has shown that more than a third of cancer patients in Europe use complementary and alternative medicine (CAM), to increase [...]
read moreTargeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer.
Abstract Over the last two decades, extensive research on plant-based medicinal compounds has revealed exciting and important pharmacological properties and activities of triterpenoids. Fruits, vegetables, cereals, pulses, herbs and medicinal plants are all considered to be biological sources of these triterpenoids, which have attracted great attention especially for their potent anti-inflammatory and anti-cancer activities. Published [...]
read more