Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil.
Medicinal plants and culinary herbs with anti-angiogenic and little toxicity properties have gained importance. Non-toxic anti-angiogenic phytochemicals are useful in combating cancer by preventing the formation of new blood vessels to support the tumor growth. We have investigated the essential oil of Origanum onites L. (OOEO), for a possible anti-angiogenic activity. OOEO was analyzed by [...]
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Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and Nuclear Factor-κB and Signal Transducers and Activators of Transcription 3 Potential antiangiogenic mechanism of silibinin in advanced lung tumor cells in A/J mice. Silibinin inhibits the production and secretion of cytokines and interleukins via inhibition of TAMs. Furthermore, silibinin [...]
read moreSilibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.
Silibinin inhibits mouse lung tumorigenesis in part by targeting tumor microenvironment. Tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) can be pro- or anti-tumorigenic, but in lung cancer cell lines they induce pro-inflammatory enzymes cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS). Accordingly, here we examined mechanism of silibinin action on TNF-α + IFN-γ (hereafter referred as [...]
read moreInactivation of Nuclear Factor κB by Soy Isoflavone Genistein Contributes to Increased Apoptosis Induced by Chemotherapeutic Agents in Human Cancer Cells
Li Yw, Fakhara A, Shadan A, et al. Cancer Res August 1, 2005 65; 6934. doi: 10.1158/0008-5472.CAN-04-4604 Cancer chemotherapeutic strategies commonly require multiple agents. However, use of multiple agents contributes to added toxicity resulting in poor treatment outcome. Thus, combination chemotherapy must be optimized to increase tumor response and at the same time lower its [...]
read moreEpicatechin gallate (ECG) and catechin gallate (CG) are superior to epigallocatechin gallate (ECGC) in growth suppression and anti-inflammatory activities in pancreatic tumour cells
Epicatechin gallate (ECG) and catechin gallate (CG) are superior to epigallocatechin gallate (ECGC) in growth suppression and anti-inflammatory activities in pancreatic tumour cells Green tea catechins are considered as possible cancer preventive agents for several cancer types but little is known regarding their effects on pancreatic cancer cells. The best studied catechin and the major [...]
read moreCancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models
Antitumor B (ATB), also known as Zeng Sheng Ping, is a Chinese herbal mixture composed of six plants. Previously, clinical studies have shown a significant chemopreventive efficacy of ATB against human esophageal and lung cancers. In the present study, A/J mice harboring a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf and treated with benzo[a]pyrene were [...]
read moreProtection of p53 Wild Type Cells From Taxol by Genistein in the Combined Treatment of Lung Cancer
This study specifies the basic principles to selectively kill p53-deficient cells (H1299, FaDu) by taxol and to protect p53 wild type cells (A549) by the prior administration of structurally related flavonoids (apigenin, genistein, and quercetin). Cytotoxic and cytostatic properties of flavonoids were investigated in vitro by flow cytometry and were compared to known anticancer drugs [...]
read moreCurcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs
Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and curry powder in the West), has been consumed by people for centuries as a dietary component and for a variety of proinflammatory ailments. Extensive research within the last decade in cell culture and in rodents [...]
read moreCancer screening among patients with advanced cancer.
A sizeable proportion of patients with advanced cancer continue to undergo cancer screening tests that do not have a meaningful likelihood of providing benefit. Screening for diseases is accepted as valuable by most physicians and patients. However, screening in patients with terminal illnesses, for whom long-term preventive benefit is nil, would seem to be a [...]
read moreEffect of Pingfei Oral Liquid on the Distribution of Mast Cells and Expression of IL- 6 in Radiation Pneumonia Rats
Liu, X., Pan, L., Li, H., Xu, B., Jin, Yy., Jia, J., Li, Pw. & Cheng, Zq. Traditional Chinese Drug Research & Clinical Pharmacology. Traditional Chinese Drug Research & Clinical Pharmacology. 2009-04. DOI CNKI:SUN:ZYXY.0.2009-04-005 Objective: To investigate the effect of Pingfei Oral Liquid (POL) on the distribution of mast cells (MCs) and the expression of [...]
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