Anti-inflammatory and anti-tumoural effects of triterpene acids found in Ganoderma lucidum and Perilla frutescens
A series of lanostane-type triterpene acids, including eleven lucidenic acids (3, 4, 9, 10, 13-19) and six ganoderic acids (20-22, 24, 26, 27), as well as six sterols (28-33), all isolated from the fruiting bodies of the fungus Ganoderma lucidum, were examined for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) [...]
read moreDietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumour promotion response.
Ferric nitrilotriacetate (Fe-NTA) is a potent nephrotoxicant and a renal carcinogen that induces its effect by causing oxidative stress. The present study was undertaken to explore protective effect of silymarin, a flavonolignan from milk thistle (Silybum marianum), against Fe-NTA mediated renal oxidative stress, inflammation and tumour promotion response along with elucidation of the implicated mechanism(s).
read moreInflammation, Chinese Medicine and Breast Cancer
Evidence has emerged in the last two decades that at the molecular level most chronic diseases, including cancer, are caused by a dysregulated inflammatory response. The identification of transcription factors such as NF-κB, AP-1 and STAT3 and their gene products such as tumour necrosis factor, interleukin-1 (IL-1), interleukin-6 (IL-6), chemokines, cyclooxygenase-2 (COX-2), 5 lipooxygenase (5-LOX), [...]
read moreSilymarin protects against renal cancer and acts plausibly by virtue of its antioxidant, anti-inflammatory and antiproliferative activities.
Ferric nitrilotriacetate (Fe-NTA) is a potent nephrotoxicant and a renal carcinogen that induces its effect by causing oxidative stress. The present study was undertaken to explore protective effect of silymarin, a flavonolignan from milk thistle (Silybum marianum), against Fe-NTA mediated renal oxidative stress, inflammation and tumour promotion response along with elucidation of the implicated mechanism(s). [...]
read moreCell Adhesion Molecules: Role and Clinical Significance in CancerCell Adhesion Molecules: Role and Clinical Significance in Cancer
The metastatic dissemination of tumour cells is the leading cause of morbidity and mortality in patients with cancer, since it designates the transition from a localised, potentially curable to a generalised, usually incurable disease. Tumour metastasis is considered to be a multi-step process characterised by a high degree of complexity. More specifically, the metastatic cascade [...]
read moreAn approach for understanding the inflammation and cancer relationship;
An approach for understanding the inflammation and cancer relationship; Chronic and persistent inflammation contributes to cancer development and can predispose to carcinogenesis. Using Huang Bai (Cortex Phellodendri) and Huang Qin Radix Scutellariae) in cancer treatment
read moreEpidemiological studies have revealed that chronic inflammation predisposes to different forms of cancer.
Epidemiological studies have revealed that chronic inflammation predisposes to different forms of cancer. Selected extrinsic inflammatory conditions increase the risk of cancer and an inflammatory component is also present also in the microenvironment of tumours epidemiologically unrelated to inflammation. An intrinsic (driven by genetic events that cause neoplasia) and an extrinsic (driven by inflammatory conditions [...]
read moreMore on Inflammation and Breast Cancer
The expression of transcripts of cytokines of the interleukin-6 (IL-6) family has been examined in human breast tumours, breast cancer cell lines, and adipose stromal cells, by means of reverse transcription polymerase chain reaction amplification.
read moreInflammation and Depression in Cancer
Several studies have tried to link cytokines, especially IL-6, to depression in patients with and without cancer (Musselman et al 2001; Sluzewska et al 1996). This study (Jehn et al 2010) demonstrates a linear relationship between IL-6 plasma concentrations and level of depressive mood.
read moreCombined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen.
Sustained chronic inflammation in the prostate promotes prostate carcinogenesis. Since an elevated level of prostate-specific antigen (PSA) per se reflects the presence of inflammation in the prostate, intervention to improve the PSA value might potentially have beneficial effects for the prevention of the development of prostate cancer. Isoflavones and curcumin have anti-inflammatory and anti-oxidant properties.
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