Innate inflammation and cancer: Is it time for cancer prevention?
Giorgio Trinchieri. F1000 Med Reports 2011, 3:11 (doi: 10.3410/M3-11) The electronic version of this article is the complete one and can be found at: http://f1000.com/reports/m/3/11. An adapted version of this article has been published in The Scientist magazine: http://www.the-scientist.com/2011/4/1/38/1/ Abstract Recently, studies have been reported indicating that daily aspirin treatment for a period of 5 [...]
read moreInflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer
Danese S and Mantovani A. Oncogene 29, 3313-3323 (10 June 2010) | doi:10.1038/onc.2010.109 Colon cancer represents a paradigm for the connection between inflammation and cancer in terms of epidemiology and mechanistic studies in preclinical models. Key components of cancer promoting inflammation include master transcription factors (for example, nuclear factor κB, STAT3), proinflammatory cytokines (for example, [...]
read moreMicrobial deprivation, inflammation and cancer
Sufficient exposure to a large variety of microbes is likely crucial for the development of a normally functioning immune system and for prevention of cancerous growths. The modern lifestyles may reduce this substantially, and, therefore, further studies to unravel the potential influence of microbial exposure on tumorigenesis are highly warranted and might pave a way [...]
read moreTocotrienols: Inflammation and Cancer
Inflammation is an organism’s response to environmental assaults. It can be classified as acute inflammation that leads to therapeutic recovery or chronic inflammation, which may lead to the development of cancer and other ailments. Genetic changes that occur within cancer cells themselves are responsible for many aspects of cancer development but are dependent on ancillary [...]
read moreDifferent patterns of inflammation and prognosis in invasive carcinoma of the breast.
Inflammation in carcinoma of the breast may represent an immune response to the tumour, but there is evidence that this response is impaired. Inflammation may also stimulate tumour growth by releasing proteolytic enzymes and angiogenic factors. Evidence from animal models suggests that the cell- mediated immune response to tumours is more important than humoural immunity [...]
read moreRole of Phytoestrogens in Inflammation
Inflammation Inflammation is a biological response of vascular tissue and is important for immune response and wound healing (Darby & Hewitson, 2007). However, in cancer, inflammation can create a microenvironment around the tumor, resulting in the attraction of chemokines, cytokines, selectins, and tumor-associated macrophages. Instead of their normal function of phagocytosis of tumor cells, they [...]
read moreInflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression
Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Moreover, accumulated clinical and experimental data indicate that the outcome of an immune response toward an evolving breast neoplasm is largely determined by the type of immune response elicited. Acute tumor-directed immune [...]
read moreSuppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action.
BACKGROUND: Breast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammation and cancer for many years in China. The purpose of this study is to investigate the activity of BER against highly-metastatic human breast cancer [...]
read moreCritical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.
The process of metastasis is not random. Rather, it consists of a series of linked, sequential steps that must be completed by tumor cells if a metastasis is to develop.
read moreAvenanthramides Inhibit Proliferation of Human Colon Cancer Cell Lines In Vitro
A high intake of whole grain foods is associated with reduced risk of colon cancer, but the mechanism underlying this protection has yet to be elucidated. Chronic inflammation and associated cyclooxygenase-2 (COX-2) expression in the colon epithelium are causally related to epithelial carcinogenesis, proliferation, and tumor growth. We examined the effect of avenanthramides (Avns), unique [...]
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