Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells
Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells Inflammatory mediators are known to play a key role in tumorigenesis, therefore, it is a promising strategy to inhibit the inflammation for cancer prevention and/or treatment. Current study was performed to [...]
read moreAnimal Models for Colon Cancer Chemoprevention. Encyclopedia of Cancer, Second Edition Elsevier Science (USA). Volume 1
Animal Models for Colon Cancer Chemoprevention. Encyclopedia of Cancer, Second Edition Elsevier Science (USA). Volume 1 Colorectal cancer is a tumor of colon and rectum, which occurs with high frequency in both men and women in Western countries. Most cases of colorectal cancers arise in a benign adenoma; some evidence suggests that some cancers arise [...]
read moreMyelophil, a mixture of Astragali Radix and Salviae Radix extract, moderates toxic side effects of fluorouracil in mice.
BACKGROUND: Anticancer-therapy-induced side effects are closely associated with life span and quality of life in cancer patients, so reducing or preventing these has been a major issue in cancer treatment. Astragali Radix and Salviae Radix extract, Myelophil, has been used to treat mainly gastrointestinal cancer patients with post-therapeutic complications such as leukopenia, anemia or severe [...]
read moreChinese Herbs and Isolates in Cancer Cell ROS
Inspecting the history of drug development during the past half century demonstrates that natural resources represent a significant segment on the pharmaceutical market compared to randomly synthesized compounds. As compiled by the World Health Organization, more than 21,000 plant species have been used worldwide in herbal medicines. Herbs are an important source for drug development. [...]
read moreMechanistic issues concerning cancer prevention by tea catechins
Mechanistic issues concerning cancer prevention by tea catechins The cancer preventive activities of tea (Camellia sinensis, Theaceae) have been demonstrated in animal models for cancers at different organ sites and suggested by some epidemiological studies. Many mechanisms for cancer prevention have been proposed based on studies in cell lines, which demonstrated the modulation of signal [...]
read morePossible mechanism of growth inhibition by Scutellaria baicalensis in an estrogen-responsive mouse tumor cell line.
We have studied the effects of Saiboku-to, a traditional Chinese medicine having suppressive activities for leukotriene production and release, on the proliferation of the estrogen-responsive mouse Leydig tumor cell line B-1F. In our previous reports, it is shown that Saiboku-to promotes, but Scutellaria baicalensis, one of the components (herbs) of Saiboku-to, significantly inhibits the proliferation [...]
read moreHighlight on the studies of anticancer drugs derived from plants in China.
Guided by the experience of traditional Chinese medicine, several new drugs have been found. Indirubin from Indigofera tinctoria is useful for the treatment of chronic myelocytic leukemia. Irisquinone from Iris latea pallasii and 10-hydroxy camptothecin from Camptotheca accuminata have exhibited definite activity on rodent tumors. Recent studies indicate that ginsenoside Rh2 is an inducer of [...]
read moreOleanolic acid and ursolic acid have been shown to act at various stages of tumor development to inhibit tumor initiation and promotion
Oleanolic acid and ursolic acid have been shown to act at various stages of tumor development to inhibit tumor initiation and promotion, as well as to induce tumor cell differentiation and apoptosis. In the two-stage mouse skin carcinogenesis model, the protection of oleanolic acid against 12-Oteradecanoyl phorbol-13-acetate promoted carcinogenesis is associated with inhibition of aberrant [...]
read moreThe Yin and Yang actions of North American ginseng root in modulating the immune function of macrophages
Background Immuno-modulatory effects of ginseng, including both immuno-stimulatory and immuno-suppressive effects, have been widely reported. This study aims to determine whether the paradoxical immuno-modulatory effect is related to unique phytochemical profiles of different North American (NA) ginseng, namely aqueous (AQ) and alcoholic (ALC) extracts. Methods AQ and ALC extracts were prepared and their immuno-bioactivity were [...]
read moreDichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
Dichloroacetic acid, often abbreviated DCA, is the chemical compound with formula CHCl2COOH. It is an acid, an analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salts and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA have been studied [...]
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