p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells.
p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. Chen NH, Zhong JJ. Phytomedicine. 2011 Jun 15;18(8-9):719-25. Epub 2011 Feb 25. The function of p53 induced by ganoderic acids (GAs) in anti-invasion was unknown, although our previous work reported the inhibition of tumor invasion and metastasis by Ganoderic acid T [...]
read moreAssessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil.
Medicinal plants and culinary herbs with anti-angiogenic and little toxicity properties have gained importance. Non-toxic anti-angiogenic phytochemicals are useful in combating cancer by preventing the formation of new blood vessels to support the tumor growth. We have investigated the essential oil of Origanum onites L. (OOEO), for a possible anti-angiogenic activity. OOEO was analyzed by [...]
read moreBisphenol A alters the development of the rhesus monkey mammary gland
Tharp AP, Maffini MV, Hunt PA, et al. PNAS May 7, 2012, doi: 10.1073/pnas.1120488109 The xenoestrogen bisphenol A (BPA) used in the manufacturing of various plastics and resins for food packaging and consumer products has been shown to produce numerous endocrine and developmental effects in rodents. Exposure to low doses of BPA during fetal mammary [...]
read moreMultivitamin use and breast cancer outcomes in women with early-stage breast cancer: the Life After Cancer Epidemiology study.
Little is known about the relation of multivitamin use to breast cancer outcomes. 2,236 women diagnosed from 1997 to 2000 with early-stage breast cancer (Stage I ≥ 1 cm, II, or IIIA) were enrolled about 2 years post-diagnosis, primarily from the Kaiser Permanente Northern California Cancer Registry (83%). Multivitamin use pre-diagnosis and post-diagnosis was assessed [...]
read moreClassification of evidence: This study provides Class II evidence that vitamin E supplementation significantly reduces the relative risk of developing signs or symptoms of neurotoxicity (relative risk = 0.14) (95% confidence interval = 0.02–1.00, p < 0.05).
We determined if soy isoflavones have dose-related oestrogenic and methylation effects. Thirty-four healthy premenopausal women were randomised to 40 mg or 140 mg isoflavones daily through one menstrual cycle. Breast specific and systemic oestrogenic effects were assessed measuring the oestrogenic marker complement (C)3 and changes in cytology, whereas methylation assessment of 5 cancer related genes [...]
read moreKorean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen Activator
Ho Y-L, Li K-C, Chao W, et al. Evidence-Based Complementary and Alternative Medicine. Volume 2012 (2012), doi:10.1155/2012/965846 Korean red ginseng and ginsenosides have been claimed to possess wide spectrum of medicinal effects, of which anticancer effect is one. The present study was undertaken to investigate the antimetastatic effect of Korean red ginseng on human hepatoma [...]
read morePsoralidin, an Herbal Molecule from Psoralea corylifolia, Inhibits Phosphatidylinositol 3-Kinase–Mediated Akt Signaling in Androgen-Independent Prostate Cancer Cells
Kumar R, Srinivasan S, Koduru S, et al. Cancer Prev Res March 2009 2; 234. doi: 10.1158/1940-6207.CAPR-08-0129 The protein kinase Akt plays an important role in cell proliferation and survival in many cancers, including prostate cancer. Due to its kinase activity, it serves as a molecular conduit for inhibiting apoptosis and promoting angiogenesis in most [...]
read moreCurcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways
Curcumin is a principal compound of turmeric, commonly used to treat tumors and other diseases. However, its anti-cancer activity in human acute monocytic leukemia THP-1 cells is not clear. This study aimed to study the anti-cancer effect and action of curcumin on THP-1 cells. Methods THP-1 parental cells and PMA-treated THP-1 cells, were used as [...]
read moreThe Effect of Polysaccharides of Some Chinese Herbs on Mice Natural Killer (NK) Cell Activity
Fang Xunxin Liang Minrou Wang Jianhua. Pharmacology and Clinics of Chinese Materia Medica 1990-01 After 3-h culture with polysaccharide of Radix Ginseng at 37C in a CO2-inculatoi, mice NK cells could get more active (P0.01). Dose response studies showed that polysaccharide of Radix Ginseng could enhance, at concentration ranged from 30ug/ml to 120ug/ml,mice NK cell [...]
read moreAnti-proliferative and Proapoptotic Effects of Labisia pumila Ethanol Extract and Its Active Fraction in Human Melanoma HM3KO Cells
A study by Pihie et al, was to determine the anticancer potential of Labisia pumila in in vitro models. Results from the study revealed that ethanol extract of L. pumila was more cytotoxic against HM3KO cells while having reduced effects on nonmalignant cells as compared to aqueous and hexane extracts. Thus, ethanol extract was selected [...]
read more