The chemokine system and cancer
Frances R Balkwill. The Journal of Pathology. Special Issue: The Cell Biology of Disease. Volume 226, Issue 2, pages 148–157, January 2012. DOI: 10.1002/path.3029 Chemokines (chemo-attractant cytokines) are a group of small proteins that act together with their cell surface receptors, in development, normal physiology and immune responses, to direct cells to specific locations throughout [...]
read moreEpidemiological studies have revealed that chronic inflammation predisposes to different forms of cancer.
Epidemiological studies have revealed that chronic inflammation predisposes to different forms of cancer. Selected extrinsic inflammatory conditions increase the risk of cancer and an inflammatory component is also present also in the microenvironment of tumours epidemiologically unrelated to inflammation. An intrinsic (driven by genetic events that cause neoplasia) and an extrinsic (driven by inflammatory conditions [...]
read moreChemokines are little appreciated components in cancer metastasis and herbs and compounds have been known to down-regualte their activities.
Chemokines are little appreciated components in cancer metastasis and herbs and compounds have been known to down-regualte their activities. This brief introduction looks at the mechanisms of inflammation and how it is involved in tumour initiation and progression. Don’t forget to send your email address so I may send you the herb research. Remember, this [...]
read moreChemokines: CC Subfamily – CCL11 (Eotaxin)
Chemokines: CC Subfamily – CCL11 (Eotaxin) Chemokines, a superfamilly of small cytokine-like molecules, regulate leukocyte transport in the body. In recent years, we have witnessed the transition of immunotherapeutic strategies. The role of chemokines in tumour biology and the development of the host’s anti-tumour defence indicate that chemokines have therapeutic potential as adjuvants or treatments [...]
read moreEvidence has emerged in the last two decades that at the molecular level most chronic diseases, including cancer, are caused by a dysregulated inflammatory response.
Evidence has emerged in the last two decades that at the molecular level most chronic diseases, including cancer, are caused by a dysregulated inflammatory response. The identification of transcription factors such as NF-kB, AP-1 and STAT3 and their gene products such as tumour necrosis factor, interleukin-1, interleukin-6, chemokines, cyclooxygenase-2, 5 lipooxygenase, matrix metalloproteases, and vascular [...]
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