Tocotrienols fight cancer by targeting multiple cell signaling pathways.
Tocotrienols fight cancer by targeting multiple cell signaling pathways. Abstract: Cancer cells are distinguished by several distinct characteristics, such as self-sufficiency in growth signal, resistance to growth inhibition, limitless replicative potential, evasion of apoptosis, sustained angiogenesis, and tissue invasion and metastasis. Tumor cells acquire these properties due to the dysregulation of multiple genes and associated [...]
read moreLymph Node Study Shakes Pillar of Breast Cancer Care
By DENISE GRADY New York Times. Published: February 8, 2011 The discovery turns standard medical practice on its head. Surgeons have been removing lymph nodes from under the arms of breast cancer patients for 100 years, believing it would prolong women’s lives by keeping the cancer from spreading or coming back. Now, researchers report that [...]
read morePrevalence of Vitamin D Insufficiency Among Breast Cancer Survivors
Background: Recent research has linked inadequate vitamin D levels with risk of breast cancer, but there are less data regarding the actual concentrations of vitamin D in women who have survived breast cancer. The objective of this study was to determine if vitamin D insufficiency is a prevalent problem for female breast cancer survivors who [...]
read moreEstrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.
Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells. The aims of the present study were to determine the estrogenic activities of icariin (ICA) and its derivatives and their structure-estrogenic activity relationship. Therefore, icaritin (ICT) and desmethylicaritin (DICT) were derived from ICA. The estrogenic activities of ICA, ICT and DICT were [...]
read moreHyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase
Abstract The prognosis for women with breast cancer is adversely affected by the co-morbidities of obesity and diabetes mellitus (DM), which are conditions associated with elevated levels of circulating fatty acids, hyperglycaemia and hyperinsulinaemia. We investigated the effects of exposure of non-malignant and malignant human breast epithelial cells to elevated levels of fatty acids and [...]
read moreInactivation of Nuclear Factor κB by Soy Isoflavone Genistein Contributes to Increased Apoptosis Induced by Chemotherapeutic Agents in Human Cancer Cells
Li Yw, Fakhara A, Shadan A, et al. Cancer Res August 1, 2005 65; 6934. doi: 10.1158/0008-5472.CAN-04-4604 Cancer chemotherapeutic strategies commonly require multiple agents. However, use of multiple agents contributes to added toxicity resulting in poor treatment outcome. Thus, combination chemotherapy must be optimized to increase tumor response and at the same time lower its [...]
read moreDNA methylation and Cancer
DNA methylation and breast cancer DNA methylation and chromatin structure patterns are tightly linked components of the epigenome, which regulate gene expression programming. Two contradictory changes in DNA methylation patterns are observed in breast cancer; regional hypermethylation of specific genes and global hypomethylation. It is proposed here that independent mechanisms are responsible for these alterations [...]
read moreResearch – New take on breast cancer risk
Kurian, AW, et al. Breast Cancer Risk for Noncarriers of Family-Specific BRCA1 and BRCA2 Mutations: Findings From the Breast Cancer Family Registry JCO October 31, 2011 doi: 10.1200/JCO.2010.34.4440 Not all women from families with a history of breast cancer face a high risk of developing the disease, a major international study has found. It contradicts [...]
read moreTreatment – Breast cancer study backs radiotherapy
Women with breast cancer who receive radiation treatment following surgery are half as likely to have their disease return within 10 years, and are one-sixth less likely to die over a 15 year period. Experts say the findings of the latest study of the disease underline the need to improve radiotherapy provision in Australia. An [...]
read moreThe Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin
HER-2 is an important oncoprotein overexpressed in about 15–25% of breast cancers. We hypothesized that the ability of curcumin to downregulate HER-2 oncoprotein and inhibit the signal transduction pathway of PI3K/Akt, MAPK, and NF-κB activation may be important in the treatment of HER-2-overexpressed breast cancer. To examine the effect of curcumin on breast cancer cells, [...]
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